L-Methylfolate
(Metafolin®)
Natural
Folic Acid
The Form of Folate Your Body Prefers
Flat Rate Shipping:
Just $3.95 to any U.S.
address for any size order!
Since 2002:
L-Methylfolate is the one and only source of folate in
HS Fighters™ with Bioactiv Folate™ ...
- Bioactiv Folate™
is the biologically active form of folic acid
- Bioactiv Folate™
is naturally occurring and the form of folate your body
prefers
- Bioactiv Folate™
bypasses obstacles to absorbing folic acid, does not accumulate
in the blood like folic acid, and is the only form of folate
that pass through the blood-brain barrier
- Bioactiv Folate™
is so unique, the ingredient is protected under law by a
U.S. Patent as Metafolin®
- Bioactiv Folate™
has been safety tested as a dietary ingredient and registered
with the FDA as Metafolin®
Are
you converting Folic Acid to L-Methylfolate?
Folic
acid is allowed to be labeled folate or folicin. However,
none of these are the active form of folate known as L-Methylfolate
(or 5-MTHF) which your body can put to work. It takes four
separate biochemical reactions for your body to turn folic
acid into active folate:
Medical studies have shown that the conversion of folic acid
into L-Methylfolate is frequently disrupted by genetic factors,
age-related problems, medications and metabolic obstacles.1,2
- Up to 40% of adults are affected by genetic
flaws that limit the amount of folic acid converted to the
active folate (L-Methylfolate) that neutralizes homocysteine.3-10
- Transformation of folic acid into active folate
(L-Methylfolate) falls off after ingesting 200 mcg, and
is saturated at doses in the region of 400 mcg. Higher doses
result in unabsorbed folic acid circulating in the blood,
and we do not know the long term biological effects of a
lifetime of exposure to unmodified synthetic folate.1,10
Ingredients
Unlike most B vitamin formulas, HS Fighters™ with Bioactiv
Folate™ provides the active forms of folate (as L-Methylfolate)
and B12 (as Methylcobalamin) to bypass obstacles that may
limit your body's ability to absorb and transform these vitamins
into active nutrients.
Directions: Take one capsule daily, or
as recommended by a healthcare professional. HS Fighters™
does NOT contain yeast, dairy, egg, gluten, soy, wheat, sugar,
starch or artificial color, flavor or fragrance.
Quality
Assurance
Labeling for HS Fighters™ with Bioactiv Folate™
accurately represent its identity, strength, composition,
quality and purity.
HS Fighters™
is created with great care at our FDA-approved
nutraceutical facility consistently "Rated A" by the
Natural
Products Association and independent third
party inspectors. Every purchase is protected by
our Total
Satisfaction Money-Back Guarantee.
Questions? Call Us Toll Free at 1-888-246-2284
References
1 Kelly P, McPartlin J, Goggins M, Weir DG, Soctt
JM. Unmetabolozed folic acid in serum: acute studies in
subjects consuming fortified food and supplements. Am J
Clin Nutr. 1997;65:1790-5>
2 Morita H, Taguchi J, Kurihara H, Kitaoka M,
Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno
M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yakazi Y.
Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase
(MTHFR) as a risk factor of coronary artery disease. Circulation
95:2032-2036, 1997.
3 Goyette P, Christensen B, Rosenblatt DS, Rozen
R. Severe and mild mutations in cis for the methylenetetrahydrofolate
reductase (MTHFR0 gene, and description of 5 novel mutations
in MTHFR. Am. J. Hum. Genet. 59:1268-1275, 1996.
4 Bailey LB,Gregory JF. Polymorphisms of methylenetetrahydrofolate
reductase and other enzymes: metabolic significance, risks
and impact on folate requirement. J Nutr 1999;129(5):919-22.
5 Deloughery TG, Evans A, Sadeghi A, et al. Common
mutation in methylenetetrahydrofolate reductase. Correlation
with homocysteine metabolism and late-onset vascular disease.
Circulation 1996;94(12):3074-78.
6 Kim YI. Methylenetetrahydrofolate reductase
polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient
interactions in carcinogenesis. Nutr Rev 2000;58:205-17.
7 Choi S-W, Mason JB. Folate and carcinogenesis:
an integrated scheme. J Nutr 2000;130:129-32.
8 Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofolate
reductase polymorphism, plasma folate, homocysteine, and
risk of myocardial infarction in US physicians. Circulation
1996;94(10):2410-16.
9 Miyao M, Morita H, Hosoi T, et al. Association
of methylenetetrahydrofolate reductase(MTHFR) polymorphism
with bone mineral density in postmenopausal Japanese women.
Calcif Tissue Int 2000;66:190-94.
10 Lucock MD, Wild J, Smithells R, Hartley R.
Invivo characterization of the absorption and biotransformation
of pteroylglutamic acid in man: a model for future studies.
Biochem Med Metaab Biol 1989;42:30-42. |
